KeyNote Session on “Bridging the gap by leapfrogging”: Cost effective molecular diagnostics to solve health disparity in cancer

Using molecular techniques for the care of patients or population has been proven to be very effective. However, infrastructure constraints and cost constraints have limited their utility in many parts of the world.  The utilization of molecular techniques to solve health disparity will be discussed in detail. Two cancers with the highest health care disparity between the western and eastern countries are cervical cancer and pediatric acute lymphoblastic leukemia.

1. In cervical cancer, a simple Pap smear-based screening had systematically reduced disease incidence by more than 60% in the last 4 decades (NIH RePORT). More recently, HPV based molecular screening has been very effective in detecting high-risk population. However, cost constraints have limited their utility. We present data utilizing next-generation sequencing and a paper chip-based method (Rodriguez et al.) to show that low-cost screening methods can be easily implemented for effective population-based screening. 
2. Pediatric B-acute lymphoblastic leukemia is another disease with an outcome disparity; while 95% of pediatric B-ALL is curable in western countries, more than 80% of pediatric leukemia do not survive 5 years in eastern countries. The use of NGS based sequencing technologies have guided high-risk, low-risk subgroups and furthermore enabled precision medicine, dosage adjustments for appropriately triaging and treating patients with ALL.

Finally, treatment selection and modification of Ph+ ALL in adults using molecular techniques can lead to significantly better outcomes.

Rajan Dewar MD PhD

University of Michigan, USA

Rajan Dewar has completed his MD at Madras University, Ph.D. from IIT Bombay. After completing his graduate studies at UT Southwestern Medical center, he trained as a pathologist at Yale and his fellowships in Hematopathology & Molecular Pathology at Stanford University School of Medicine. Before moving to The University of Michigan as the director of the hematology laboratory, he was at Harvard Medical School for a decade, where he started his global health implementation research. He has published more than 45 papers in reputed journals and has been leading several social research and social entrepreneurial activities in the United States and India.

CHECK THE FULL PROGRAM HERE →→ 

https://molecularmedicine.conferenceseries.com/scientific-program

Efficient and cost-effective cancer treatment model by using nuclear radiation

In 21st century, the major biological problem in a living organism is cancer. Lots of people die due to this disease because of no proper remediation and the cost of the medicine. So, we are proposing a minimum cost and efficient treatment model by the help of neutron radiation. In this model, we are covering energy, radiation, efficiency, cost and availability as our main aspects. The role of radiation in cancer treatment is the destruction and controlling the growth of cancer cells. Here, the major nuclear phenomenon utilized is neutron capture reaction followed by the release of gamma rays which is the main component for the destruction of cancer cells. 

To reduce the effect of neutron radiation we inject ‘Boron’ enriched in the form of boron-10 (B^10). This particular isotope of boron has got a very high neutron absorption cross-section leading to the excess neutron capture which may damage other non-harmful living cells of the living organism. Boron NeutronCollection (BNCT) Treatment is biochemical target radiotherapy based on atomic infections and decay reactions, which occurs when radioactive borides are irradiated with high linear term neutrons, element components. Natural boron, which transmits energy to alpha particles and returns lithium 7. Clinical significance of BNCT is mainly focused on high-level glioma treatment, recurrent head and neck cancer and primary or metastatic melanoma. The source of BNCT neutron is currently limited to a specially modified nuclear reactor, so the cost of material is high.so we are Proposing a Cost-Effective Cancer Treatment Model by Using Nuclear Radiation.

Radiationtherapy (also referred to as radiotherapy) is a cancer treatment that uses high doses of radiation to kill cancer cells and shrink tumors. At low doses, radiation is used in x-rays. Radiation therapy doesn't kill cancer cells directly. Radiation therapy can be expensive. It uses complex machines and involves the services of many health care providers. Neutron medical care may be an extremely effective kind of actinotherapy. Long-term experience with treating cancer has shown that certain tumor types (pathologies) are very difficult to kill using conventional radiation therapy.

Oral presentation by Vishal Uttam Dhakane, Pandit Deendayal Petroleum University, India.

He has served as faculty of Chemical engineering in Reputed research institute VJTI and now he is the Teaching assistant of Chemistry in PDPU. He has published 3 papers in reputed journals

Check More about this session: Molecular Oncology

Precision Medicine: What it Mean for Your Health?

Precision Medicine is an approach that permits doctors to choose treatments by understanding the genetic cause of patient sickness. Precision medicine, sometimes called personalized medicine, is an approach for protecting the health and treating a disease that considers a person’s genes, behaviors, and environment. Precision drugs are most popular in areas of cancer analysis. Immunotherapy is a new approach that harnesses the power of our immune systems to identify and control diseases such as cancer. Using the genetic changes in the patient,  their treatment is understood.

Precision genetics provides a customized approach to testing, diagnosing, and treating cancer. Instead of employing a one-size-fits-all approach  here are some ways in which a precision drug approach will shield your health:

Predict susceptibility to disease

Improve disease detection

Pre-empt disease progression

Customize disease-prevention strategies

Prescribe more effective drugs

Avoid prescribing drugs with predictable side effects

The ancient follow usually misses its mark - every person’s genetic makeup is completely different from others,  which have a vital effect on health. Our understanding of genetics and the way they drive health, sickness and drug responses in everyone make doctors supply higher sickness interference, more correct diagnoses, safer drug prescriptions and simpler treatments for the numerous diseases and conditions that diminish our health. Tailoring health care to every person’s distinctive genetic makeup – that’s the promising plan behind Precision Drugs.

Benefits of Precision Medicine

Uses Family Health History

Screen for Diseases Before You Get Sick

Tailoring Prevention

Tailoring Treatments

Finding and Tracking Infectious Diseases

Eliminate trial-and-error inefficiencies that inflate health care prices and undermine patient care.

Throughout history, the follow of traditional medication has mostly been reactive. Even today, we tend to wait till the onset of diseases then attempts to treat or cure them. Our efforts to treat these major diseases like Cancer, Alzheimer’s and diabetes which are caused by Genetic and environmental factors are often imprecise, unpredictable and ineffective.

The drugs and treatments we devise are tested on broad populations and are prescribed using statistical averages. Consequently, they work for a few patients not for several others, due to genetic differences among the population. On average, any given medicinal drug currently on the market solely works for half people.